Besides chromatin remodeler genes such as ARID1A, other epigenetic regulatory genes (e.g., lysine methyltransferase genes KTM2C and KTM2D) were often affected by somatic variants (Figures 3 and S2) resembling our previous findings from LS‐associated colorectal tumors.46 The gene discussed is ARID1A; the disease is Leigh syndrome.