ATM and congenital adrenal hyperplasia: As examples of shared COSMIC gene variants between hyperplasia and carcinoma, CAH of LEC22 showed a PIK3CA p.(Glu542Lys) variant that has been linked to progression into EC,36 and synchronous hyperplasia and EC samples from LEC15 shared ARID1A, ATM, and PIK3CA variants (Figure 2A).