As examples of shared COSMIC gene variants between hyperplasia and carcinoma, CAH of LEC22 showed a PIK3CA p.(Glu542Lys) variant that has been linked to progression into EC,36 and synchronous hyperplasia and EC samples from LEC15 shared ARID1A, ATM, and PIK3CA variants (Figure 2A). The gene discussed is PIK3CA; the disease is congenital adrenal hyperplasia.