KRAS and infection: Specifically, NS1 enhances viral protein synthesis (3), NS2 binds ssRNA and recruits structural proteins that form viral inclusion bodies (4), NS3 is involved in mature viral assembly and release (5), NS4 regulates innate immune responses and antagonizes both type I interferon signaling with NS3, thus enhancing BTV replication (6), and NS5 localizes to the nucleolus and then diffuses within the nucleus and cytoplasm, thereby preventing degradation of ribosomal RNA during infection and reducing host protein synthesis (2).