SOD1 and amyotrophic lateral sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Patients with Amyotrophic Lateral Sclerosis (ALS) Carrying Superoxide Dismutase 1 (SOD1) Gene Mutations