The expression of mutant huntingtin within glial cells plays a significant role in the exacerbating neurotoxicity.21 Several studies indicate that microglia and astrocytes are the primary cell types driving neuroinflammation in HD.20 Microglia have been demonstrated to be key drivers of neuroinflammation in HD, with early activation detectable in presymptomatic gene carriers up to 15 years before predicted onset, which correlates with disease severity and neuronal loss in affected regions,22,23. The gene discussed is HTT; the disease is Huntington disease.