PPARGC1A and Huntington disease: Furthermore, attenuating mHTT's effects on peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), a key regulator of MBP production and cholesterol synthesis in oligodendrocytes, may ameliorate early myelin dysregulation.53,54 These studies shed light on the molecular mechanisms underlying white matter damage in HD and suggest potential therapeutic targets for mitigating oligodendrocyte dysfunction and myelin abnormalities in the disease.