PRKG2 and multiple sclerosis: Knocking down PRKG2 using CRISPR/Cas9 further confirmed that abnormal PRKG2 activity enhances mHTT binding to MYRF, affecting its function.52 Reduced PRKG2 levels lead to a decrease in phosphorylated Ser259-MYRF, releasing MYRF from the mHTT bond and restoring its normal activity.52 The myelin repair effect of LAQ was also demonstrated in YAC128 mice, showing independence from inflammatory regulation, as LAQ acted by regulating inflammation in the treatment of multiple sclerosis.42