This study investigated platelet-derived growth factor receptor beta-positive (Pdgfrb<sup>+</sup>) pericyte dynamics and reprogramming in GBM vasculature.<h4>Methods</h4>We generated GL261-Luc and GL261-CFP glioblastoma cells via lentiviral transduction and established two transgenic models. Here, PDGFRB is linked to glioblastoma.