CXCL12 and diabetic kidney disease: Notably, the plasma levels of VEGF-D and CXCL-12 levels used to assess the ROC curve area in the macroalbuminuria group, microalbuminuria group, and normal albuminuria group were higher than the VEGF-C level This suggests that plasma levels of VEGF-C, VEGF-D, and CXCL-12 have some value for early diagnosis of DKD and assessment of disease severity, as shown in Figure 4(A–C), and detailed in Tables 4–6.