Compared with the control group, the expression levels of plasma VEGF-C, VEGF-D, and CXCL-12 in the macroalbuminuria group, microalbuminuria group, and normoalbuminuria group gradually increased with the progression of DKD, in the following order: macroalbuminuria group > microalbuminuria group > normal albuminuria group > control group. This evidence concerns the gene VEGFC and diabetic kidney disease.