Notably, the plasma levels of VEGF-D and CXCL-12 levels used to assess the ROC curve area in the macroalbuminuria group, microalbuminuria group, and normal albuminuria group were higher than the VEGF-C level This suggests that plasma levels of VEGF-C, VEGF-D, and CXCL-12 have some value for early diagnosis of DKD and assessment of disease severity, as shown in Figure 4(A–C), and detailed in Tables 4–6. This evidence concerns the gene VEGFD and diabetic kidney disease.