Previous studies have identified rs10168266 as part of an extended haplotype that encompasses rs7582694, rs7568275, and rs7574865—a locus associated with augmented STAT4 expression and hyperresponsiveness to IL-12/IFN-⍺ signaling in SLE and RA (Namjou et al., 2009). The gene discussed is STAT4; the disease is systemic lupus erythematosus.