The Dsm1 locus on mouse chromosome 5 identifies Gabra2 as a key modifier gene, whose expression correlates with thermosensitive seizure susceptibility and survival in DS mice; clobazam targeting Gabra2 elevates seizure thresholds dose-dependently by enhancing GABAergic signaling, linking background genetics to SCN1A haploinsufficiency (Hawkins et al., 2016). This evidence concerns the gene SCN1A and Dravet syndrome.