DDX3X and Burkitt lymphoma: Importantly, somatic loss of function (LOF) mutations that inactivate the helicase domain on one allele of the DDX3X gene are frequent in BL (>30% of cases) (Richter et al., 2012; Bouska et al., 2017; Kaymaz et al., 2017; Moffitt and Dave, 2017; Grande et al., 2019; Lopez et al., 2019) and occur preferentially (>90%) in males.