A study published in CANCER LETTERS indicates that CRC cells that overexpress CXCR4 utilize extracellular vesicles to transport various miRNAs (such as miR-25-3p, miR-130b-3p, and miR-425-5p) to macrophages, thereby activating the PTEN/PI3K/Akt signaling pathway and prompting macrophages to polarize towards the M2 phenotype. This evidence concerns the gene CXCR4 and colorectal carcinoma.