The overexpression of miR-122 enhanced the proliferation and migration of MC38 cells while suppressing the expression of NEGR1. NEGR1 knockdown activated the PI3K/AKT pathway, facilitated M2 macrophage polarization and IL-10 secretion, and expedited liver metastasis of colorectal cancer in vivo (Dai et al., 2024). This evidence concerns the gene NEGR1 and colorectal cancer.