Wang et al. revealed that CXCR4 upregulation in CRC cells mediates Evs-dependent transfer of specific miRNAs (miR-25-3p, miR-130b-3p, miR-425-5p) to macrophages, driving their M2 polarization through PTEN suppression-mediated PI3K/Akt pathway activation. Here, CXCR4 is linked to colorectal carcinoma.