SMARCA4 and colorectal cancer: A study published in Cancer Research demonstrated that M2 macrophage-derived extracellular vesicles are abundant in miRNAs that penetrate colorectal cancer cells and associate with the coding sequence of BRG1, a recognized pivotal promoter of colorectal cancer metastasis, thereby expediting the invasion and metastasis of colorectal cancer (Lan et al., 2019).