ORC6 and malignant colon neoplasm: For example, the KCNQ1OT1/miR-484/ANKRD36 axis is involved in the development of colon cancer, while the KCNQ1OT1/miR-181a-5p/PCGF2 axis is associated with metastasis in rectal cancer; The SNHG1/miR-484/ORC6 axis plays a role in colon cancer, while the SNHG1/miR-423-5p/EZH2 and SNHG1/let-7b-5p/ATP6V1F axes are involved in the development and metastasis of rectal cancer, respectively (Qi et al., 2020).