Zhang et al. discovered that miR-192-5p effectively targeted interleukin-1 receptor-associated kinase 1 (IRAK1), prompting myocardial infiltrating macrophages to predominantly adopt the M2 phenotype, thereby successfully safeguarding mice from the fatal viral myocarditis induced by coxsackievirus B3 (CVB3) (Zhang et al., 2020). This evidence concerns the gene IRAK1 and viral myocarditis.