The findings indicate that the H99 reference allele provoked a robust pro-inflammatory response, as evidenced by its strong induction of IL-12p70 and IL-17. IL-12p70 is crucial for Th1 polarization and subsequent IFN-γ production, so its approximately three-fold higher level with H99 (Figure 4) suggests that this strain may promote a strong Th1 immune response, which is important for controlling cryptococcal infection [19]. This evidence concerns the gene IFNG and cryptococcosis.