INSR and polycystic ovary syndrome: Inadequate insulin signalling can influence bone remodelling by reducing bone formation and increasing bone resorption.[5] Mechanisms being investigated are decreased osteoprotegerin (OPG) expression, an inhibitor of a member of the tumour necrosis factor family (RANKL) involved in bone resorption, and insulin receptor expression in osteoclasts impacting their recruitment.[5] However, the precise mechanism is still not fully understood, and the clinical significance is unclear, which makes further research on the link between PCOS, osteoporosis and insulin necessary.