Bidirectional Effects on Erythropoiesis: While ASXL1 truncations repress erythroid differentiation via GATA1/KLF1 silencing (contributing to anemia), concomitant H3K27me3 loss at proliferative loci (e.g., HOXA9) may paradoxically expand early erythroid progenitors. The gene discussed is KLF1; the disease is anemia.