SIX1 and Wilms tumor: While we are unaware of genetic somatic inactivation of BCL11A as a driver of Wilms tumors, BCL11A is indeed one of the most highly downregulated transcripts in SIX1-mutant WT, which notably form a related subset of WT characterized by a pre-induction metanephric mesenchyme gene expression profile and often associated with DROSHA mutations, as seen in this case (10, 15).