BCL11A and hydronephrosis: Notably, while there are no known reports of WTs in individuals with germline deletions or duplications involving BCL11A (2p15p16.1 deletion or duplication syndrome), renal anomalies such as multicystic kidneys and hydronephrosis have been reported in this related condition, suggesting that perhaps inactivation of BCL11A may be involved in physiologic renal development, although these syndromes include many additional adjacent genes, in addition to BCL11A, which may instead be contributory (12).