The antitumor mechanism of MEHPPs is mainly divided into two kinds: (1) MEHPPs directly act on tumor cells, change the expression levels of key proteins and enzymes in tumor cell signal transduction pathways, inhibit tumor cell growth, proliferation, migration, and invasion to induce tumor cell apoptosis; (2) MEHPPs, as a biological immune response modulators, enhance the immune function of the body by promoting the activity of LAK and natural killer cells (NK), inducing macrophages to produce tumor necrosis factor, and indirectly inhibit or kill tumor cells. The gene discussed is TNF; the disease is neoplasm.