AKT1 and Insulin resistance: evaluated the therapeutic effect of Pueraria lobata root polysaccharide (PLP) on diabetic metabolic syndrome, and found that PLP down‐regulates the mRNA expression of PEPCK, G6PC, FOXO1, SREBP‐1, and ACC in liver, which plays an antidiabetic role via activating PI3K/AKT signaling pathway, thereby improving insulin resistance, glucose and lipid metabolism in db/db mice (Ren et al. 2015).