TFDG reduces the proliferation of prostate cancer cells by influencing the PKCδ/aSMase signaling pathway, which is linked to the expression of the 67 kDa laminin receptor (67LR)TFDG suppresses tumor growth while enhancing the phosphorylation of PKCδ and the expression of aSMase in tumor xenograft models. This evidence concerns the gene SMPD1 and prostate carcinoma.