TFDG improves the phosphorylation of Chk2 to influence the balance of pro‐apoptotic and anti‐apoptotic Bcl‐2 family proteins, thereby triggering intrinsic apoptosis in a p53‐dependent mannerTFDG elevates the expression of death receptors to stimulate extrinsic apoptosis in OVCAR‐3 human ovarian carcinoma cellsThe expression of p27 was increased by TF3, leading to G0/G1 cell cycle arrest in OVCAR‐3 cells. The gene discussed is BCL2; the disease is ovarian carcinoma.