Furthermore, we identified the key bioactive compounds in ECT (Sachaliside, Naringenin, Liquiritigenin, maclurin, and Rhapontigenin) and elucidated its underlying LPS‐TLR4/MyD88/NF‐κB signaling pathway in mitigating obesity‐induced oxidative stress and inflammatory responses. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.