MYD88 and obesity due to melanocortin 4 receptor deficiency: By measuring liver oxidative stress levels, serum inflammatory factor levels, as well as lipid and LPS levels in the serum, combined with molecular docking experiments of the main core components, the study further clarified the material basis of ECT in regulating obesity and found possible regulatory pathways (TLR4/MyD88/NF‐κB) of ECT.