ADORA2A and delirium: Dexmedetomidine (DMED), a highly selective α2-adrenergic receptor (α2-AR) agonist, exerts pharmacological effects by acting on α2-AR in the central nervous system and the periphery (Chima et al., 2022), Its effects include sedation, analgesia, hypnosis, the antisympathetic effects, anxiolysis, delirium reduction, anti-inflammatory properties, and protection of vital organs.