miRNA-212 was identified as a regulator of ventricular hypertrophy by its direct modulation of Foxo3. Recent reports indicate that the inhibition of miR-199a resulted in the reversal of ventricular hypertrophy by restoring mitochondrial fatty acid oxidation via the modulation of PGC-1α (Yan et al., 2021). This evidence concerns the gene FOXO3 and cardiac hypertrophy.