SPOP has been identified as a novel E3 ligase for LATS1 in ccRCC cells, with the E3 ubiquitin ligase Cullin3/SPOP mediating the stability of LATS1 through polyubiquitination, leading to its degradation in a degron-dependent manner in renal carcinoma. The gene discussed is SPOP; the disease is nonpapillary renal cell carcinoma.