SPOP (spotted POZ protein), a substrate-interacting junction protein within the Cullin 3-based E3 ubiquitin ligase complex, exhibits a mutation rate of 10%–15% and is a critical molecular feature of prostate cancer (PCa) (Wang Z. et al., 2020; Liu D. et al., 2021). The gene discussed is SPOP; the disease is prostate carcinoma.