Additionally, high PGK1 expression is significantly associated with poor prognostic features, including low differentiation, advanced TNM staging, lymph node metastasis, and tumor diameter ≥1.0 cm, reinforcing the critical role of PGK1 in the progression of thyroid papillary carcinoma. The gene discussed is PGK1; the disease is metastatic malignant neoplasm in the lymph nodes.