Furthermore, in a short-term study on patients with mild to moderate knee osteoarthritis, Marouf et al. found that resveratrol combined with meloxicam reduced pain severity and inflammatory markers (TNF-α, IL-1β, IL-6, and C-reactive protein) compared to placebo and meloxicam alone (Marouf et al., 2018). This evidence concerns the gene TNF and osteoarthritis, knee.