MAPT and Alzheimer disease: The pathogenesis of AD remains unclear, but its primary pathological features include the accumulation of amyloid-beta (Aβ) plaques, neurofibrillary tangles due to tau protein hyperphosphorylation, chronic neuroinflammation, synaptic dysfunction, and oxidative stress (Migliore et al., 2005; Duyckaerts et al., 2009).