A DM for IBD was then constructed by integrating the expression levels of these 13 model genes with the regression coefficients from the LASSO model, resulting in the following RiskScore formula: RiskScore=BHLHE40*1.880263188+EDN1*−0.739172108+EGR1*0.194906128+ENG*1.914504876+HIF1A*−0.473313989+HK2* 0.59283215+IL1B* 0.354144093+IL6 *−0.421088826+MMP2*0.455838964+MMP9*−0.406781925+NOS2*0.578376745+PPARG * 0.250999791+SPP1 * 0.545610438. Here, HK2 is linked to inflammatory bowel disease.