Significant expression differences were observed, with most HRDEGs (ADM, BHLHE40, CCL2, CD274, COL1A1, EGR1, ENG, FLT1, FOS, HIF1A, HK2, IL1B, IL6, KDR, MMP2, MMP9, NOS2, PTGS2, SERPINE1, SPP1, and TEK) being upregulated in IBD samples, while EDN1 and PPARG were downregulated. The gene discussed is HIF1A; the disease is inflammatory bowel disease.