SNCA and synucleinopathy: By using the sequential combination of ionexchange and hydrophobic chromatography, we produced a highly purified targetprotein (≥97% purity) which corresponds to recombinant monomericα-synuclein and that may be successfully used in further functional tests.Such high purity and homogeneity of α-synuclein are the key factors inmaintaining the reproducibility of laboratory tests for synucleinopathies.