Meanwhile,the patient had an elevated expression level of the BCR::ABL/p210 oncogene andincreased number of tumor cells, which correlated with leukemia progression(Fig. 2).Interestingly, the nine-nucleotide insertion associated with the replacementof lysine by four new amino acid residues is located in the SH3 contact siteof the tyrosine kinase domain of BCR::ABL. The gene discussed is EVPL; the disease is neoplasm.