Dyrk1A was previously found to be involved in thephosphorylation of several targeting proteins, including Amph1, which alsopossesses an SPSQ motif [30].Interestingly, increased expression of Dyrk1A was recently detected in B-ALL(BCR::ABL/p190+) [31]. Here, CNTNAP1 is linked to acute lymphoblastic leukemia.