Dyrk1A was previously found to be involved in thephosphorylation of several targeting proteins, including Amph1, which alsopossesses an SPSQ motif [30].Interestingly, increased expression of Dyrk1A was recently detected in B-ALL(BCR::ABL/p190+) [31]. The gene discussed is AMPH; the disease is acute lymphoblastic leukemia.