Considering that Metrnl functions as an adipokine, a recent study that attracted our attention demonstrated that Metrnl activates the PPARα-CPT1A pathway to enhance fatty acid oxidation, thereby inhibiting abnormal lipid accumulation in nucleus pulposus cells, which reduces inflammation and attenuates intervertebral disc degeneration (46). Here, METRNL is linked to Intervertebral disk degeneration.