After probiotic fermentation, Morinda citrifolia significantly alleviated AD symptoms such as infiltration of inflammatory cells (e.g., mast cells and eosinophils), reduced the levels of IgE, TSLP and beneficially modulated the expressions of Th1, Th2(, Th17, and Th22)-mediated cytokines in lesioned skin and splenocytes (82). The gene discussed is IGHE; the disease is Alzheimer disease.