The concentrations of Th2 cytokines (IL-4, IL-5, and IL-13), which are known to contribute to the development of AD, were significantly decreased compared with the negative control group after 7 weeks (40) and 2 weeks (41), and a study has reported that IL-4 and IL-13 were significantly decreased in 1 weeks (42). Here, IL4 is linked to Alzheimer disease.