Furthermore, human studies have further confirmed this mechanism: the expression of NLRP3 and GSDMD-N (pyroptosis execution protein) is significantly increased in peripheral blood mononuclear cells (PBMCs) of ARDS patients, and their levels are positively correlated with the decrease in oxygenation index and disease severity scores, suggesting that the degree of pyroptosis directly affects clinical prognosis (92). The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.