HMGB1 and acute respiratory distress syndrome: Studies have shown that in the LPS-induced ALI model, necroptosis of alveolar epithelial cells is significantly increased, accompanied by the release of a large number of inflammatory mediators, such as high mobility group protein B1 (HMGB1), etc., which act as DAMPs to further activate immune cells, amplify the inflammatory response, and aggravate lung tissue injury (123).