One study revealed that resveratrol can suppress the release of IL-8 and granulocyte-macrophage colony-stimulating factor (GM-CSF) by more than 50% in alveolar macrophages from smokers with COPD under in vitro conditions, highlighting its potent anti-inflammatory effects in the context of COPD (72). The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.