KRAS and colorectal carcinoma: Noteworthy, KRAS, M3 and Methylation combination possessed the most predictive ability with AUC value elevated to 0.920 (Confidence Interval: 0.881-0.960), which were better than any pairwise combinations (Figure 4J); and this combination harbored the highest AUC value 0.931 in early CRC and 0.886 in advanced CRC (Figures 4K, L).