Dysregulation of PPARGC1A/PGC-1α, GPX4, and NFE2L2/NRF2 transcripts was evident in disease burden analyses and was increased in early disease PD monocytes but declined in later stages; SIRT1 transcripts were elevated early and throughout disease staging, while SIRT3 declined later in disease. Here, NFE2L2 is linked to Parkinson disease.