Prior studies have shown that individuals with active TB have greater levels of immunosuppressive cytokines such TGF-β and IL-10 as well as FoxP3+Treg cells wherein the FoxP3 mRNA expression is regulated through the secretion of interleukin 10 (IL-10) or transforming growth factor beta (TGF-β) (54, 55). The gene discussed is TGFB1; the disease is tuberculosis.