Intriguingly, the TME exhibits heightened PD-1+ cell infiltration in non-GCB DLBCL subsets characterized by CD30-/CD5-/EBER-phenotypes (72% vs 28%, p = 0.003), mirroring the striking survival disparity between GCB and non-GCB subtypes (5-year OS: 68% vs 41%, p < 0.001) [37]. Here, CD5 is linked to diffuse large B-cell lymphoma.