MAPT and Alzheimer disease: As the role of metabolism is often neglected in mathematical models of AD, it is interesting to observe that parameters related to insulin and glucose regulation, such as Ins0, the baseline insulin concentration, λInsG, the glycogen synthase kinase 3 (GSK-3) dynamics G0, the baseline concentration of GSK-3 and dG, the autonomous decay rate of GSK-3, have significant impacts with respect to both neuronal density and tau concentration.