SQSTM1 and Hepatic fibrosis: For example, stress-induced tribbles pseudokinase 3 (TRIB3) interacted with sequestosome 1 (SQSTM1) to enhance the secretion of INHBA/Activin A-rich exosomes from hepatocytes, thereby activating hepatic stellate cells (HSCs) and promoting liver fibrosis (Zhang et al., 2020).