In this study, among the seven selected loci of HLA-DQA1/DQB1 genes (rs1391371, rs9272425, rs9272426, rs9272460, rs9273368, rs9273505, and rs9274666), we also observed that the risk of GDM increased correspondingly with the accumulation of unfavorable genotypes when combined. Here, HLA-DQA1 is linked to gestational diabetes.