Although studies have explored the relationship between HLA-related genes and genetic susceptibility to GDM, identifying significant polymorphisms such as HLA-DQB10602 are being negatively associated with GDM risk (3, 23), the role of SNPs in the HLA-DQA1 and HLA-DQB1 genes in GDM pathogenesis remains unclear. This evidence concerns the gene HLA-DQB1 and gestational diabetes.