In this study, HED, MG, THJ, LCME, AG and SCU could inhibit inflammation, SMS, PNS and EZP could inhibit oxidative stress, NG-R1, SaB and SYC could inhibit myocardial fibrosis, and RSV, ZJSF and MLF improve DCM by promoting autophagy. Here, SH3BP5 is linked to familial dilated cardiomyopathy.