CP is the key region that produces CSF in the brain, which plays crucial roles in protecting the central nervous system (CNS) and is widely considered as the neurofluid in the glymphatic system that works to remove metabolic wastes, including Aβ and tau proteins in AD (Zhou et al., 2024; Agarwal et al., 2024; Iliff et al., 2012; Ozsahin et al., 2025). The gene discussed is MAPT; the disease is Alzheimer disease.