Seita et al. (2020), Chan et al. (2022), and Yoshimatsu et al. (2022) generated transgenic macaques carrying multiple APP mutation; tauopathies were not identified probably because the monkeys were young at the time of necropsy. The generation of models with multiple mutations may speed up the development of pathology, yet it is not the most clinically relevant as multiple mutations are rare in human populations. Thus far, no groups have reported germline or embryonic modification of MAPT in NHPs. Here, MAPT is linked to tauopathy.