In the context of fatty liver disease, Gorgens et al. (2019) revealed that hepatocyte‐specific siRNA‐mediated Dpp4 knockout reduced hepatic steatosis in db/db mice, while we have also recently shown reduced hepatic fibrosis, as evidenced by Picosirius red staining and mRNA expression of immunological pathways in Dpp4hep−/− mice (Trzaskalski et al., 2022). This evidence concerns the gene DPP4 and fatty liver disease.