DPP4 and heart failure: This study evaluates how diastolic function and molecular signatures of heart failure, like inflammation and fibrosis, are affected in male Dpp4+/+, Dpp4−/−, and Dpp4flox/flox mice injected with a TBG‐CRE to selectively eliminate DPP4 from hepatocytes (Dpp4hep−/−) and respective controls (Dpp4GFP), aged and fed an HFHC diet for 24 weeks.