Moreover, while all cells within the NVU are capable of producing Aβ peptides due to APP expression in all NVU cell types, research on the expression of APP, BACE1, and ADAM10 and their influence on Aβ production have so far been limited to neurons.35 Therefore, objective 2 focuses on investigating the post-transcriptional regulation of APP, BACE1, and ADAM10 mRNA expression by microRNAs in neurons, drawing primarily from Alzheimer’s disease literature but of high interest for future CAA research. The gene discussed is BACE1; the disease is early-onset autosomal dominant Alzheimer disease.