APP and Stroke: This was particularly seen in a middle cerebral artery occlusion (MCAO) stroke model of 5xFAD mice (which overexpress APP and PSEN1, leading to severe amyloid angiopathy).42 After stroke, endothelial-specific reductions in genes like Sox18 and Cxcl12 altered cerebral EC-neuron communication.43 As such, this could highlight the importance of endothelial-neuronal signaling in regulating Aβ clearance.