BACE1 and Alzheimer disease: Herein the miR-29a/b-1 cluster was identified as suppressor of BACE1 protein expression (and not BACE1 mRNA expression suggesting no transcriptional regulation of mRNA expression).78 Also, the loss of function of the miR-29a/b-1 cluster in brain biopsies from patients with AD significantly elevated BACE1 protein levels, which were not region specific.78