In the specific network situation characterizing Dravet syndrome, the consequences of the sodium voltage‐gated channel alpha subunit 1 (SCN1A) genetic variants and the resulting interneuronopathy can be worsened by non‐selective modulators of voltage‐gated sodium channels.12, 13, 14. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.