CDKL5 and Encephalopathy: As discussed intensely by Bertocchi et al.,147 mice with a Cdkl5 knockout or Cdkl5 gene variant and mouse models of glutamate ionotropic receptor N‐methyl‐d‐aspartate (NMDA) (GRIN)‐related encephalopathies carrying mutations in genes encoding one of the NMDA receptor subunits represent examples of DEE models, which do not exhibit relevant seizure activity.