In our analysis, both TNFRSF18 and CXCL13 exhibited markedly higher expression levels in exhausted CD8+ T cells from tumour tissues relative to those from adjacent non‐tumorous tissues, indicating that TNFRSF18 may serve as an additional biomarker for identifying exhausted CD8+ T cells in the tumour. The gene discussed is TNFRSF18; the disease is neoplasm.