PPP2CA and cancer: Protein phosphatase 2A (PP2A) is a pivotal serine/threonine phosphatase, comprising a holoenzyme complex with a scaffolding (A), regulatory (B), and catalytic (C) subunit, is pivotal in cellular regulation and widely acknowledged as a tumor suppressor in various solid malignancies [8, 9], as the primary catalytic subunit responsible for dephosphorylation, PPP2CA plays a pivotal role in cancer progression, with its downregulation closely linked to malignancy.