Figure 1 shows the ADC metrics and microstructural parameter maps for five representative breast cancer patients with different IHC factor status and molecular subtypes. The overall ADC values decreased with longer diffusion time, i.e. ADCPGSE < ADC25Hz < ADC50Hz. As shown in the red boxes, the lower ADC and kin, higher ΔADC and vin were observed in the ER(+)/PR(+) case compared to the negative case. Besides, d was found to be larger in the HER2(+) case. This evidence concerns the gene ESR1 and breast cancer.