Silencing of ASF1B significantly represses colorectal cancer cell proliferation, migration, invasion, stemness and epithelial mesenchymal transition progression via the PI3K/AKT pathway.58 However, the precise involvement of ASF1B in each tumor type needs be explored further.59 However, the relevance of ASF1B in rectal cancer radiation and chemotherapy resistance has not been thoroughly researched or debated. The gene discussed is AKT1; the disease is rectal cancer.