HNRNPL, named as heterogeneous nuclear ribonucleoprotein L. As a member of the hnRNP family, it exhibits an essential function in the occurrence and development of bladder cancer, gastric cancer as well as other cancers.36,37 Wang et al. 38 reported that HNRNPL was elevated in CRC, and HNRNPL reduction suppressed cell growth as well as metastasis. This evidence concerns the gene HNRNPL and cancer.