SRSF1 and cancer: ASF1 in mammals is made up of two homologous proteins, ASF1A and ASF1B.52 Overexpression of ASF1B has been associated with tumor growth and metastasis in various malignancies, including lung adenocarcinoma53, cervical cancer54, hepatocellular carcinoma55, breast cancer56, and thyroid carcinoma.57 ASF1B is strongly expressed in most tumor tissues relative to normal tissues, according to a pan-cancer investigation, and there is a link between ASF1B expression and clinical prognosis.