ATG12 and colorectal cancer: For example, Hu et al. discovered that miRNA-214 was highly expressed in radiosensitive colorectal cancer specimens and negatively correlated with the plasma level of CEA, and discovered that miRNA-214 was able to enhance colorectal cancer radiation sensitivity by inhibiting ATG12-mediated autophagy phenomenon.63 This study built a network of miRNAs and transcription factors predicting the upstream of the six hub genes to fully understand the sixhub-gene roles as well as potential mechanisms on READ radio-responsiveness as well as prognosis.