EGFR and neoplasm: Elevated RRM2 mRNA expression was linked to poor chemosensitivity as well as adverse prognosis.34 Moreover, the upregulation of RRM2 also induces chemo-resistance to cisplatin and fluorouracil (5-FU) via activating epidermal growth factor receptor (EGFR)/AKT proliferative pathway.35 RRM2 elevation impacts intricate pathways for the mediation of tumor survival, growth, apoptosis as well as chemoresistance.