SERPING1 and neoplasm: Our study is the first to prove coagulation genes could regulate the MSC senescence, creating a link between coagulation enzymes and cellular senescence and aging [51]. Furthermore, inhibition of SERPING1 did not affect the normal function of cell proliferation or alter MSC identity (Fig. 3H–I), suggesting that SERPING1 presents a tumor suppressor-independent marker for ameliorating inflammaging.