GLP1R level was significantly associated with a reduced risk of MDD (odds ratio [OR] = 0·9988, 95% confidence interval [CI] = 0·9978-0·9999, P = 0·0291) and of BD (OR = 0·9990, 95% CI = 0·9982-0·9998, P = 0·0182). Here, GLP1R is linked to major depressive disorder.